Welcome to a new generation of memory protection.

After hundreds of millions of dollars invested and 15 years of rigorous scientific research, including clinical testing with over 2,000 individuals¹ in 68 European, 50 U.S. and 17 Canadian medical centres, VIVIMIND™ is now available for consumers.

For an aging population, VIVIMIND™ represents a breakthrough in one of the key consequences of getting older - memory loss. VIVIMIND™ is a science-based natural health product that has been shown to protect memory function based on the naturally occurring ingredient, homotaurine, found in seaweed.

How does VIVIMIND™ work?

As we age, certain brain regions start to shrink. This shrinkage reflects loss of brain cells. One brain region in which brain cell loss occurs is the hippocampus, a region responsible for learning and memory. Shrinkage of the hippocampus has been associated with learning and memory problems².

Why does the loss of brain cells in the hippocampal region occur? Experts believe that the buildup of certain toxic proteins^3-4 called beta-amyloid (or A-beta) is detrimental to the brain. When these proteins reach excessive levels, they cause neurons (brain cells) within the brain to malfunction and die. When neurons are damaged or die, signaling problems occur in the brain that ultimately affect memory and learning abilities³.

VIVIMIND™ is a patented product based on the naturally occurring ingredient homotaurine, which binds to A-beta proteins and reduces the deposition and toxic effects of these proteins in the brain⁴.

In a groundbreaking study performed in Canada and the United States using brain scans (magnetic resonance imaging (MRI)), VIVIMIND™ was shown to significantly reduce the loss of brain volume in the hippocampus. In fact, VIVIMIND™ was proven to preserve 68% more brain volume versus placebo (like a sugar pill)⁵.

Individuals taking VIVIMIND™ also performed better on memory and thinking tests compared with individuals taking placebo. VIVIMIND™ was found to improve cognitive performance (verbal skills, memory, comprehension ability, planning and execution skills) by 33% versus placebo⁵.

VIVIMIND™:

• Protects the brain structure associated with memory and learning: The hippocampus is a region associated with learning and memory². VIVIMIND™ can help reduce the loss of volume of this very important region of the brain⁵.

• Preserves memory: You know how you can be introduced to someone and forget their name two minutes later? Don't worry, because you're not alone². VIVIMIND™ can support you in maintaining your ability to remember things like people's names⁵.

• Sustains brain cell health: As you age, it is normal to lose brain cells². VIVIMIND™ can help protect your brain cells during the normal course of aging⁴.

• Maintains verbal skills and comprehension ability: VIVIMIND™ can help you maintain your level of verbal comprehension and your overall quality of speech⁵. So when you're telling a story or making a presentation, VIVIMIND™ can help you maintain your train of thought.

• Supports planning and execution skills: You've just arrived at your vacation destination and you suddenly remember you forgot to cancel your newspaper subscription. VIVIMIND™ can help you maintain your ability to go from the initial planning to remembering everything you need to make it a trip you'll never forget⁵.

What is the recommended dosage?

VIVIMIND™ should be taken daily and should be swallowed whole (not crushed, blended or mixed). The recommended adult (18 years of age and older) dose is one to two tablets twice a day (in the morning and evening preferably at mealtime). If a dose is missed, do not double the dose to make up for the missed dose – simply start again at the next scheduled dose. Each tablet of VIVIMIND™ contains 50 mg of homotaurine.

What is the safety profile?

While VIVIMIND™ is generally well tolerated at the recommended dose, some people may experience nausea, weight loss, dizziness or fainting. In many cases, symptoms are temporary. If they persist, contact your healthcare professional.

Can VIVIMIND™ be used with other natural products or medications?

Metabolism studies suggest that interactions between VIVIMIND™ and other products are not likely to occur⁶. No specific interaction studies were conducted with other products. For further information, contact your healthcare professional.

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¹North American and European phase 3 clinical trials – data on file BELLUS Health.
²The Johns Hopkins White Papers. Rabins PV, MEMORY Johns Hopkins Medicine, Baltimore, Maryland, 2008.
³Aisen PS et al. A Phase II study targeting amyloid-β with 3APS in mild-to-moderate Alzheimer disease. Neurology 2006;67:1757-1763. http://www.neurology.org/cgi/content/full/67/10/1757.
⁴Gervais F et al. Targeting soluble Aβ peptide with Tramiprosate for the treatment of brain amyloidosis. Neurobiology of Aging 2007; (28):536-547.
⁵Post-hoc analysis of a 78-week Phase III North American study in 1052 mild-to-moderate Alzheimer’s disease patients 50 and older.
⁶Metabolism studies - data on file BELLUS Health.